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三阴性乳腺癌(TNBC)在各乳腺癌亚型中复发率和死亡率最高。其特点是雌激素受体(ER)、孕激素受体(PR)和人表皮生长因子受体2(HER2)表达阴性。根治性手术治疗是首选方案,而化学治疗是TNBC辅助治疗的基础。随着乳腺癌分子生物学研究进展,针对TNBC的靶向、免疫治疗等新药有了新进展,促使TNBC治疗模式不断改进,使患者获益。尽管如此,TNBC的诊治依然困难重重。就当前TNBC治疗策略及临床研究进展作一综述,旨在为临床诊治TNBC提供参考依据。
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基本信息:
中图分类号:R737.9
引用信息:
[1]孙亚飞,徐图,陈超波.三阴性乳腺癌治疗的研究进展[J].中国现代普通外科进展,2024,27(09):714-719.
基金信息:
无锡市卫生健康委中青年拔尖人才资助计划(HB2023116)